The IAA One Minute Blog

Researchers say they have identified a gene mutation that causes the skin disease psoriasis.

Gene Mutation Discovery

Psoriasis is a chronic inflammatory condition that causes red, scaly, itchy patches on the skin.

Researchers used a mouse model to identify a mutation in a gene known as IKBKB that causes a group of immune cells, called regulating T-cells, to misfire.

These cells are normally gatekeepers of the immune system; however the mutation causes them to contribute to inflammation.

What is Psoriasis

Psoriasis is a skin disease that causes a rash with itchy, scaly patches, most commonly on the knees, elbows, trunk, and scalp. Common signs of psoriasis include:

• A patchy rash that varies widely in how it looks from person to person
• Cyclic rashes that flare for a few weeks or months and then subside
• Dry, cracked skin that may bleed
• Itching, burning or soreness
• Rashes that vary in color
• Small scaling spots

Psoriasis is a chronic condition with no cure. Treatments are available to help manage symptoms.

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